Overexpression of cytochrome P450 4F2 in mice increases 20-hydroxyeicosatetraenoic acid production and arterial blood pressure
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چکیده
منابع مشابه
Increased blood pressure in mice lacking cytochrome P450 2J5.
The cytochrome P450 (CYP) enzymes participate in a wide range of biochemical functions, including metabolism of arachidonic acid and steroid hormones. Mouse CYP2J5 is abundant in the kidney where its products, the cis-epoxyeicosatrienoic acids (EETs), modulate sodium transport and vascular tone. To define the physiological role of CYP2J5 in the kidney, knockout mice were generated using a conve...
متن کاملCytochrome P-450 under pressure: more evidence for a link between 20-hydroxyeicosatetraenoic acid and hypertension.
Considerable evidence links the metabolism of arachidonic acid by cytochrome P-450 (CYP) enzymes with the regulation of vascular tone and homeostasis as well as renal function. The enzymes in question fall into 2 classes: the epoxygenases, which generate vasodilator epoxyeicosatrienoic acids (EETs), and the / -1 hydroxylases, which generate the constrictor 20-hydroxyeicosatetraenoic acid (20-HE...
متن کاملRenal arterial 20-hydroxyeicosatetraenoic acid levels: regulation by cyclooxygenase.
20-HETE, a potent vasoconstrictor, is generated by cytochrome P-450 omega-hydroxylases and is the principal eicosanoid produced by preglomerular microvessels. It is released from preglomerular microvessels by ANG II and is subject to metabolism by cyclooxygenase (COX). Because low-salt (LS) intake stimulates the renin-angiotensin system and induces renal cortical COX-2 expression, we examined 2...
متن کاملVascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension.
Epidemiological evidence suggests a role for sex-dependent mechanisms in the pathophysiology of hypertension. It has been shown that 5alpha-dihydrotestosterone (DHT) administration (56 mg/kg of body weight per day IP for 14 days) increases blood pressure, cytochrome P450 4A expression, and 20-hydroxyeicosatetraenoic acid synthesis in rats. We examined whether increased vascular 20-hydroxyeicosa...
متن کاملRole of 20-hydroxyeicosatetraenoic acid (20-HETE) in vascular system.
Cytochrome P450s (P450) metabolize arachidonic acid (AA) to hydroxyeicosatetraenoic acids (HETEs) and epoxyeicosatrienoic acids (EETs). Among these eicosanoids, 20-HETE is formed in a tissue and cell-specific fashion and plays an important role in the regulation of vascular tone in the brain, kidney, heart and splanchnic beds. 20-HETE is a potent vasoconstrictor produced in vascular smooth musc...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2009
ISSN: 0085-2538
DOI: 10.1038/ki.2009.281